The Canadian Alliance in Cold Spray Technology (CACST) is a Canadian-wide research and innovation partnership to bridge the gap between fundamental research and application through equitable participation of experts, and well-defined path to commercialization. A holistic approach toward the innovation in cold spray (CS) technology is the mechanism through which its partners would be benefitted by joining the forces and acquiring much needed advanced infrastructures. In the context of global competitive landscape, mainly the European counterpart, the current proposal will position Canada as a global leader in CS technology. To accomplish this, a holistic approach toward the innovation in CS technology is key, whereby research partnership and collaboration engaging grassroot fundamental research by universities, leveraging discoveries to reach medium technology readiness level (TRL) and propelling the mid-TRL prototypes to commercial arena by industries is the differentiating characteristic of this ambitious proposal. The proposed infrastructure is a unifying multi-institutional initiative from world-renowned researchers from the Universities of New Brunswick/Waterloo/Western/Ottawa/Toronto/Sherbrook/Windsor. This unprecedented alliance has the goal of unleashing the endless possibilities of CS advanced manufacturing in creating novel materials to build disruptive processes leading to innovative products ready to be deployed in current and next generation engineering applications in transportation, energy, health, defence/security, sustainable manufacturing, forestry, and many others to meet the technology’s market readiness for Industry 4.0. The CACST project will position New Brunswick at the center of the current infrastructure proposal by focusing on building a core nanostructured powder manufacturing facility essential for any advanced manufacturing.